Exon 2被替换为一个包含S112位置上阿尔法氨基酸被丝氨酸替换的Exon 2,后跟一个用于选择目的的删除了floxed neo cassette的修饰Exon 2。这种突变型PPARgamma不具有磷酸化能力,且有更强的生物学活性。(来源:J:135904)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
Insertion, Nucleotide substitutions
--
1
10
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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