一只大鼠肌动蛋白重链启动子驱动表达的是经过修饰的鼠心肌α肌动蛋白重链(cDNA,Myh6)基因,其中1445位的G被替换为A,同时去除了468-527的密码子,导致R403G的替换以及编码蛋白的潜在结合肌动蛋白的区域缺失。这种转基因小鼠表现出轻微的表型。(来源:J:36522)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(CBA x C57BL/6)F1
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1
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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