Adgre1^m1Btlr

This mutation, which was discovered in an ENU mutagenesis screen for defective macrophage function, corresponds to an A-to-G transition at nucleotide position 1776 of the gene, in the 14th of 22 exons, that results in replacement of tyrosine by cysteine at amino acid position 579 of the protein. Macrophages from thioglycolate-elicited peritoneal exudates of homozygous mutant mice exhibit greatly reduced surface expression of the EMR1 (F4/80) protein, and heterozygous macrophages exhibit surface EMR1 expression intermediate between that of wild-type and homozygous cells. (J:135219)