Csnk1e^tm1Asil

A floxed neo cassette was inserted downstream of a modified exon 4 containing a C to T transition at base pair 12555 (C12555T) and an additional loxP site was inserted upstream of the modified exon 4. The neo cassette was removed by germ line, cre-mediated recombination that left the modified exon 4 floxed. The transition mimics a gain of function mutation identified in hamsters as having a destabilizing effect on Per1. (J:135186)