Mir106a、Mir18b、Mir20b、Mir19b-2、Mir92-2和Mir363基因被替换成一个Frt标记的诺卡因筛选 cassette。靶向载体被导入V6.5背景的C57BL/6 x 129S4/SvJae杂交胚胎干细胞(ES)。诺卡因 cassette通过Flp介导的剔除被去除。(来源:J:134861)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count