从3号外显子到5号外显子被替换为一个EYFP和一个含floxed neo cassette的元件。通过在ES细胞中短暂表达cre,移除了这个floxed neo cassette。通过ES细胞提取物的western blot分析,确认了内源性蛋白产物的缺失。融合产物的表达也通过western blot分析得到了证实。这是一对无功能基因(null allele)和报告基因(reporter allele)。(来源:J:134591)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部