将一段含有在第256位氨基酸被截短、后面跟着IRES-GFP序列的Foxo1基因cDNA,通过CAGGS启动子(鸡β-actin启动子加上CMV增强子)插入到内皮1号。插入了内含一个可翻转的neo-STOP cassette,这种设计使得在cre激活时,只有当neo-STOP cassette被剔除时,截短的Foxo1基因cDNA才会表达。(来源:J:134336)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
插入
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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