将一段含有在第256位氨基酸被截短、后面跟着IRES-GFP序列的Foxo1基因cDNA,通过CAGGS启动子(鸡β-actin启动子加上CMV增强子)插入到内皮1号。插入了内含一个可翻转的neo-STOP cassette,这种设计使得在cre激活时,只有当neo-STOP cassette被剔除时,截短的Foxo1基因cDNA才会表达。(来源:J:134336)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count