将完整的mouse Ighmbp2 cDNA序列插入到一个修改后的5.87kb小鼠基因组片段中,该片段包含了Ttn启动子、非编码的Ttn exon 1、内含子1和Ttn exon 2的30bp缺失起始密码子区域。转基因表达仅限于心脏和骨骼肌肉,通过RT-PCR检测Ighmbp2 exon 1确认了这一点(来源:J:102748)
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cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count