将含有鸡β-actin启动子CAG,驱动表达一个包含floxed neo-STOP cassette的 cassette,后接人了编码人miR-17, 18a, 19a, 20a, 19b和92的cDNA,以及带有frt标签的IRES-EGFP cassette和poly-A序列的元件,这些元件被插入到ROSA定位点。这个等位基因也是一个敲入突变,通过Cre介导去除neo-STOP cassette后,可以表达其中的人类miRNAs。 (来源:J:133215)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入
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31

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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