杂交瘤M86产生了一种能识别αGal碳水化合物抗原的天然抗体。来自杂交瘤M86的重组κ轻链被用来替换ES细胞中的κ轻链簇。经过生殖传递后,这些小鼠与一个Cre敲除品系杂交,以去除新霉素选择标记。基因组PCR确认了靶向的正确性。(来源:J:133032)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S4/SvJae
Targeted
Insertion, Intergenic deletion
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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