在第12外显子上游插入了loxP位点,而在第14外显子下游则插入了FRT标记的诺卡因抗性基因座。这些小鼠与FLPe转基因小鼠杂交,以去除诺卡因抗性基因座,使得12-14号外显子被loxP位点所 flank。基因靶向的有效性通过基因组PCR得到了确认。(来源:J:132803)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv
Targeted
插入
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1
2
17

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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