在基因的3' UTR区域插入了IRES-creER cassette、四环素抗性基因和Frt引导的诺卡因选择标记。通过与C57BL/6背景的Flp重组酶转基因品交配,去除了诺卡因选择标记。接着,Flp基因从这条线中纯化出来。当与Tg(CAG-Bgeo/ALPP)1Lbe报告型品系杂交,并给予他莫昔芬处理后,检测到了cre表达在视网膜的ganglion细胞和horizontal细胞,以及大脑中少数神经元中。(来源:J:144315)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入
--
1
5
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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