一段带有SV40内含子和poly-A序列的人类RET cDNA,后面跟着带有poly-A和frt-flanked neo cassette的CFP,这些都被插入到了exon 1中,去除了包括起始的甲硫氨酸密码子和前6个氨基酸的信号肽编码序列。通过小鼠的生殖细胞中使用flp介导的重组,neo cassette被移除,留下一个floxed RET和CFP cassette(来源:J:132854)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入,基因内删除
--
1
23
18

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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