Exon 17周围通过同源重组插入了loxP位点和一个含floxed neo cassette的片段。随后,通过体内Cre介导的重组,neo cassette和Exon 17被移除,导致产生插入、早终止密码子和缩短的蛋白质。PCR检测证实了携带这种等位基因的小鼠中存在0.4kb的剪切转录本。(来源:J:131043)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count