The PrP-SMN transgene was designed with the mouse prion protein gene (PrP or Prnp) promoter region and exon 1 and 2, full-length SMN cDNA (containing exons 1-8), and two SV40 polyA signals. Mice from founder line 92 (PrP92-SMN) were found to have 8-9 copies of the transgene. (J:131663)