他设计的HSA-SMN转基因包含了人类α骨骼肌肌动蛋白(HSA或ACTA1)的启动子区域、SV40 VP1内含子的剪接接受位点、全长的人类SMN基因(包含1-8号外显子)以及两个SV40的polyA信号。来自创始系63(HSA63-SMN)的老鼠被发现携带着5个这种转基因拷贝。(来源:J:97103, J:131663)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/N
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插入
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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