从346到380的基因序列被替换成了一个IRES-lacZ-neo插件。通过脑组织提取物的 Western blot 分析,确认没有蛋白质产物产生。这是一项无产物基因突变。(来源:J:129963)
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The genomic sequence for codon 346 through 380 was replaced with an IRES-lacZ-neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. This is a null allele. (J:129963)