在exon 12的3'端插入了floxed neo cassette,然后在exon 12的5'端增加了一个loxP位点。短暂的Cre表达导致neo cassette和exon 12被剔除。蛋白质产物的缺失通过脑组织的Western blot分析和免疫组化检测得到了确认(来源:J:131058)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count