Pkhd1^tm1Som

A 0.8 kb fragment, which contains part of exon 4 that encodes the terminal 46 amino acids and part of intron 4, was replaced with a neo cassette. The presence of two truncated transcripts (one lacking part of exon 4 and exon 5, and the other lacking all of exon 4) was confirmd by RT-PCR analysis on kindey and liver extracts. (J:131370)