从一个能识别Histone 4家族成员C端17肽,通过H2-Kb呈现的CD8+ T细胞群体中,克隆出了重排的Valpha2-SGTGGYKV的TCRalpha链和Vbeta8.3-SGTGGSAETL的TCRbeta链。重组基因片段被插入到TCR表达载体中,然后注入到blastocytes中。这个突变株的特点是转基因TCR表现出“多态”表达,大约28%的CD8+ T细胞带有这种转基因TCR。(来源:J:131347)
Basic Information
either: C57BL/6 or (CBA x C57BL/6)F2
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count