在exon 1下游插入了一个floxed neo cassette,而在exon 1上游则增加了一个loxP位点。短暂表达的Cre重组酶去除了neo cassette和exon 1。通过对总胸腺细胞提取物进行 Western blot 分析,确认了没有蛋白质产物产生。(来源:J:131287)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
--
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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