在 intron 1 中插入了带有floxed neo cassette的元件,并通过Cre介导的重组移除。同时,GFP cassette被插入到exon 2的框架中,取代了起始密码子。融合转录本和蛋白的表达通过Northern和Western blot分析在正常水平以下得到了确认(来源:J:131281, J:212391)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
3
47

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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