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中文
在exon 4的第91位，通过插入两个突变（CGA替换为TGG），引入了arginine到tryptophan的错义突变（R91W）。为了定位目的，还插入了内含子6的floxed Neo抗性基因座。创始小鼠与删除小鼠杂交以去除Neo抗性基因座，留下一个loxP位点。根据视网膜提取物的Western印迹，突变蛋白水平相对于野生型对照减少了95%。（来源：J:130076）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
