在内皮5号染色体上插入了含floxed neo cassette的neo cassette,通过同源重组在内皮7号染色体插入了第三个loxP位点。通过体内Cre介导的重组,去除了floxed neo cassette,使得6号和7号外显子被loxP位点 flank。(来源:J:129846)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count