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中文
一个包含完整人类肾素基因的15-kb基因片段，包括5'端3KB的上游区域和3'端3KB的下游区域，被用来构建转基因小鼠。估计拷贝数不少于2个。转基因小鼠的肾中检测到大量人类肾素的mRNA，大脑、肺、胸腺、睾丸和脾脏也有显著表达。心脏、胰腺和胃的表达量较低。除了8-12号线，还创造了8-3和8-5号线，但它们的表达水平比8-12号线要低。（来源：J:129503）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
