一个人类的MAPT cDNA,编码含有441个氨基酸、包含4个重复序列的最长tau蛋白亚型,其中2个N端插入已被替换为鼠源内源基因。鼠源的Mapt蛋白不表达,而插入的人源基因在P15时开始在鼠大脑中由murine Thy1启动子驱动表达。(来源:J:96869)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
14
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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