在exon 2的190bp上游和220bp下游插入了LoxP位点,同时在exon 2之后插入了带有FRT标记的诺卡因 cassette。通过基因组PCR确认了生殖细胞的遗传。检测到LoxP位点或neocassette的存在并未影响基因表达。(来源:J:128713)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count