使用了包含APOE*3等位基因、APOC1基因以及位于APOC1基因下游的肝细胞调控区(HCR)的人类基因克隆,构建了转基因小鼠。总共产生了五个转基因品系,包括393、414、428、437和453线。(来源:J:109197)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x DBA/2J)F1
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2
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16

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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