Tlr9^M2Btlr

The Cpg2 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is an A-to-T transversion at nucleotide position 3060 of the gene (Genbank Accession NM_031178) that results replacement of glutamine by leucine at amino acid position 985 of the receptor protein. (J:128405)