rsq1表型是在对 Toll-like 受体(TLR)配体响应受损的突变体进行的ENU诱变筛选中被识别出来的。这个突变发生在基因(Genbank Accession NM_133211)的第391位碱基,导致第68位氨基酸由丝氨酸替换为异亮氨酸,位于受体的第一个富含亮氨酸的重复(LRR)区域。(来源:J:128404)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Chemically induced
单点
--
1
4
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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