在翻译起始点上游300bp位置插入了loxP位点,接着在编码区域的3'末端与Frt序列随同的neo cassette也插入了loxP位点。通过体内Flp介导的重组,neo cassette被移除,使得整个编码区域被loxP位点包裹。(来源:J:128312)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count