外显子3和部分外显子4被替换了新插入的neo cassette,导致F-box区域丢失并产生了一个框移。蛋白质产物缺失通过 hippocampus组织的 Western blot 分析得到了确认(来源:J:127941)
查看原文 参与反馈
Exon 3 and part of exon 4 were replaced by a neo cassette resulting in the loss of the F-box domain and a frame shift. The loss of protein product was confirmed by western blot analysis on hippocampus extracts. (J:127941)