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中文
将包含136bp 5'和130bp 3'序列的Mirn150基因转录启动子(带有CAG驱动器和LoxP标记的neo-STOP cassette)以及ROSA26定位的基因组DNA插入。在Mirn150基因DNA和polyadenylation信号之间放置了一个Frt-flanked IRES-EGFP cassette。构建物被注入到R19胚胎干细胞中，这些细胞再被注入四倍体囊胚。通过Cre介导的neo-STOP cassette剔除，导致在所有组织中产生CAG驱动的Mirn150和EGFP。这个等位基因与Gt(ROSA)26Sortm14.1(Mirn150)Rsky和Gt(ROSA)26Sortm2.1(Mirn150)Rsky的祖先等位基因共享源。(J:127234)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
