开放阅读框被替换为带有人类PRNP变异,第129位氨基酸位置为缬氨酸的版本,以保留小鼠信号序列。表达通过 Western blot 分析进行了确认。(来源:J:105882)
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The open reading frame was replaced with the human PRNP variant with a valine at amino acid position 129 such that the mouse signal sequence was retained. Expression was confirmed by western blot analysis. (J:105882)