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中文
设计了一个靶向载体，用于将2-4号外显子替换为一个由loxP位点引导的诺卡因抗性（pgk-neo）元件。这项突变在基因的螺旋-螺旋区域（CR1）之前引入了终止密码子。为了去除含有的floxed pgk-neo片段，杂合突变雌性与CMV-cre雄性（背景为C57BL/6-129SV混种）进行了杂交。（来源：J:126871）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
