Exon 16通过Cre介导的重组被去除了。这个exon编码SH3域和鸟苷酸酶域的部分。蛋白表达缺失通过E10.5时期心脏的 Western blot 分析得到了确认(来源:J:126506)
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Exon 16 was removed by cre-mediated recombination. This exon encodes part of the SH3 domain and the guanylate kinase domain. The absence of protein expression was confirmed by western blot analysis on E10.5 hearts. (J:126506)