一种修改过的Hoxd11基因转染构建被设计,通过在exon 1的起始密码子处插入Cre编码序列,后面跟着SV40的polyadenylation信号,使得Cre重组酶在Hoxd11调控元件的驱动下表达,但不含Hoxd11的任何氨基酸残基。同源臂被添加,以定向整合到Hoxd13和Evx2之间的位置,这个区域位于簇的5'端(来源:J:82530)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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