从接受鸽子血红蛋白c免疫的小鼠5C.C7 T细胞克隆的DNA中,制备出了重组的mouse α和βTCR。α亚基的Valpha11.1-JalphaC7构建去除了3'的α增强子,而β亚基的Vbeta3-Dbeta1.1-Jbeta1.2构建包含了内源性的3'β链增强子。这个转基因在原始B10.BR背景下的CD4+细胞中表达超过95%。(来源:J:111186)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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70

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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