前三个外显子被cDNA编码的lacZ和一个pGK neo cassette替换,这样将β-半乳糖苷酶的cDNA置于内源性启动子的调控下,同时去除了内源基因。对骨骼肌和心脏的Northern和Western印迹分析确认了Ankrd2的RNA和蛋白质均不存在(来源:J:125819, J:215212)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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