前两个外显子被cDNA编码的lacZ和pGK neo cassette替换,将β-半乳糖苷酶的cDNA置于内源性启动子的调控下,同时去除了内源基因。心脏的Northern和Western印迹分析证实了Ankrd2的RNA和蛋白质均不存在。(来源:J:125819, J:215212)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count