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这些小鼠来自Ightm1.1Rsky小鼠杂交产生的嵌合鼠。当将这些嵌合鼠与表达Cre的转基因小鼠杂交时，Igh基因座的CH区域被删除，并发生靶向构建的倒位。这使得突变的Ighg1能够以正确方式表达功能蛋白。这些小鼠的B细胞仅在可溶性和膜结合形式下表达IgG1抗体。(来源：J:125719)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
