将人类类II相关恒定链基因(hIi, CD74)及其启动子的向量注入到(C57BL/6J x DBA/2J)F1杂交胚胎中。这条亚系(AR194)最初通过捐赠者进行了C57BL/6背景的纯合恒定链敲除突变小鼠的回交,随后与纯合的C57BL/6小鼠杂交,历经了超过12代。目前,这条亚系不再携带恒定链的突变。(J:88717)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x DBA/2J)F1 x C57BL/6J
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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