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在exon 1插入了一个带有核定位信号和floxed PGKneo cassette的lacZ-3pA，构建了一个无义突变基因。通过与携带Hprt1tm1(cre)Mnn基因的 mice杂交，去除了cre cassette。通过RT-PCR在纯合子小鼠中确认了转录本缺失。LacZ表达通过X-gal染色来验证。(来源：J:125184)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
