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中文
设计了一个靶向载体，包含一个位于目标基因起始密码子上游的loxP切割位点，以及在同一个外显子下游的loxP标记的PGK-Neo插入片段。这个载体被注入到了RW-4 ES细胞中。杂交胚胎随后被培育成C57BL/6小鼠，然后通过与表达广泛Cre重组酶的FVB转基因小鼠杂交，这些小鼠中的Neomycin选择性 cassette得以在后代中剔除。(来源：J:95410)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
