这个转基因包含了常激活的Gsk3b(通过S9A突变使其持续激活),它在一种被弱化的小鼠α肌动蛋白重链(Myh6)启动子,连接了七个tetO响应元件的调控下转录。为了使Myh6启动子活性降低,去除了三个GATA位点和两个甲状腺样响应元件。当与表达tetacycline转录激活蛋白或反转录激活蛋白的转基因小鼠杂交时,通过撤除或给予四环素类似物,可以控制常激活的Gsk3b在心脏特异性的表达。(来源:J:125131)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Applicable
--
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部