位于Igkj和Igkc基因群之间的轻链内含子增强子Ekappa被伊基巴(Igkh)基因座的0.8kbXbaI片段替换,这个片段包含了重链内含子增强子元素(Emu或Rr150)以及周边的矩阵附着区域。下游包含了一个floxed Neo选择标记。通过瞬时Cre重组酶的表达,移除了Neo选择标记。(来源:J:124407)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
载体插入引起的破坏
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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