在ATG起始密码子后插入了LacZ基因和一个floxed的诺卡因选择 cassette,它们删除了2到305位氨基酸编码序列。对脊髓组织进行定量RT-PCR未在纯合小鼠中检测到内源基因表达。然而,LacZ在这些纯合小鼠的多种组织中被检测到。(来源:J:124469)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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