在目标基因的第一个内含子中插入了一个FRT-flanked neo cassette后面跟着一个loxP位点,然后在第3外显子下游增加了一个loxP位点。通过将这些小鼠与表达Flpe的 mice杂交,可以剔除neo cassette,使得第2和3外显子被loxP位点所包裹。(来源:J:124126)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv
Targeted
插入
--
1
--
11

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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