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中文
在PC3 ES细胞中，目标处理针对的是Tg(Prm-cre)70Og转基因，该转基因在雄性生殖细胞中表达Cre重组酶。通过同源重组，将含有lacZ序列和一个可删除的neo cassette的靶向载体插入ES细胞。neo cassette随后随雄性嵌合鼠的传递被去除，导致了homeodomain区域的删除，并且lacZ报告基因的表达。通过RT-PCR确认了内源转录本的缺失。(来源：J:123638)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
