一个编码124个C端氨基酸的区域被替换成pgk-neo cassette。这个删除区域包含了所有锌指氨基酸,因此目标基因通过替代转录失去了产生DNA结合蛋白的能力。RT-PCR证实了突变肺部没有转录本。(来源:J:123621)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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